The effect of the child's food at early age can be mediated because of surplus of body weight at adult age as it is risk factor of arterial hypertension. The Breastfeeding (B) creates only moderate tire-tread effect concerning surplus of body weight at adult age therefore the significant effect via this mechanism is improbable.
Level of the general cholesterol and lipoproteid is an important factor of warm risk. Consider that these indicators can be programmed by events since early childhood, in particular intensity of growth and feeding in infancy.
The analysis of such interrelation showed that the average level of the general cholesterol in infancy was higher at the children who are on GV but at adults who were nursed, it was lower. In meta WHO which 23 of 37 known publications on this subject entered, the association between GV and level of cholesterol at later age is not revealed at all that is caused, in particular, by the heterogeneity of these researches caused first of all by an age difference. And still in the analysis of data on adults 19 years that the average level of cholesterol at the persons nursed was 0.18 mmol/l lower, than at raised artificially were more senior. In the analysis of similar data on children and teenagers of significant association did not find. The further analysis of subgroups showed that lasting GV more than 3 years degree of cholesterol was lower, however results were not significant. This metaanalysis shows that the association between GV and level of cholesterol depends on age. At children and teenagers of influence of GV on this indicator did not observe, but cholesterol level at the adults nursed was lower and was 5.7 mmol/l that was 3.2% lower than a similar indicator at the persons raised artificially.
Possible protective mechanisms.
Cholesterol content in breast milk significantly exceeds its content in the majority of commercial substitutes of breast milk. High consumption of cholesterol in infancy can create long-term effect of programming of synthesis of cholesterol by the descending regulation of hydroxymethyl-glyutaril-coenzyme A (HMG-CoA). This hypothesis is confirmed with pilot studies in which the high exposition to cholesterol at young animals was followed by decrease in level of cholesterol in blood at later age. So, programming of a lipidic profile of high content of cholesterol in breast milk was suggested to be considered as the potential mechanism of association between duration of GV and low level of cholesterol at later age.